17th International Conference on Cytopathology and Histopathology
Vancouver, Canada
Hira Kareem
Services Institute of Medical Sciences, Pakistan
Title: Glomerular changes in kidney of albino rats after using copper diet: A biological study
Biography
Biography: Hira Kareem
Abstract
Aim: An experimental study to evaluate the effects of copper metal on renal glomeruli. This study was conducted from May to November 2013 in the Pathology Department of the University of Health Sciences, Lahore.
Methods: 20 albino rats were selected and divided into two groups. The control group 1 was fed on standard pellet rodent diet and tap water. The experimental group 2 was fed 0.5mg/kg of body weight for 18 weeks on alternate days; the dose was calculated according to the body weight. Rats were sacrificed at the end of the experiment and the kidneys were removed for processing and H&E staining for routine histological study. Glomerular changes observed by microscope and statistically analyzed using the Chi-square test with p<0.05.
Results: Results showed that glomerular changes in terms of mesangial cell proliferation by using copper in the diet of rats. When the control group 1 on a normal diet was compared with the experimental group 2, a statistically significant difference (p<0.05) was noticed.
Conclusion: It is therefore concluded that copper in the diet affects the glomeruli in terms of mesangial cell proliferation, adhesion and crescent formation in kidneys of albino rats.