Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University China
Title: Pathogenesis and targeted treatment of skin injury in systemic lupus erythematosus
Biography: Guo-Min Deng
Skin is the second most common manifestation in patients with Systemic lupus erythematosus (SLE) yet the etiology and the mechanisms which are involved in the expression of injury remain unclear. We discuss the role of ultraviolet light (UV), immune cells, cytokines and the deposition of immunoglobulin in the development of inflammation and damage. UV represents the most typical environmental factor which triggers the expression of skin lesions in areas where immunoglobulin has been deposited and various components of the immune system have been amassed. Understanding of the interplay of environmental and immune factors has led to the identification of key molecules which can be targeted therapeutically. These include IgG/Fc receptor, tumor necrosis factor (TNF)/TNF receptor and interferon (IFN)/IFN receptor-initiated cell signaling. A number of intracellular kinases (spleen tyrosine and calcium/calmodulin 4) and transcription factors have also been demonstrated to be involved in the expression of skin lesions in lupus-prone mice. The possibility to apply small drugs locally with limited side-effects calls for further studies to eliminate the burden of skin inflammation in SLE patients.