Daniela Cristina dos Santos
São Paulo State University, Brazil
Title: Peritoneal malignant mesothelioma in young male patient: Ten years of evolution
Biography
Biography: Daniela Cristina dos Santos
Abstract
Peritoneal Malignant Mesothelioma in Young Male Patient: Ten Years of Evolution: Epithelioid peritoneal malignant mesothelioma in patient male, young, with absence of history of asbestos exposure and with supraclavicular lymph node metastasis. Abdominal ultrasonography and computed tomography showed large amount of ascites into peritoneal cavity. On gross examination, at laparoscopy abdominal, gray nodules with variable size (1 to 6 milimeters) and morphology with nodules coalescent and plaques involving peritoneal and liver surface are observed. Fine Needle Aspiration (FNA) in lymph node with Giemsa and Papanicolaou (PAP) staining show, on microscopic examination, large cell clumps with cuboidal mesothelial cells with increased nuclear to cytoplasm ratio and unclear cell borders, concentric round nuclei, conspicuous nucleoli and sparse mitotic figures. The stroma is fibrotic and myxoid. Tumor cells were positive for calretinin (strong nuclear and cytoplasmic expression), D2-40, EGFR, cytokeratin 5/6 and WT1, but were negative for MOC31, CEA, TTF-1, and Ber-EP4. We expected to contribute in the diagnosis identification with an unusual peritoneal mesothelioma in young male patient with clinic evolution more than 10 years.